UTP—glucose-1-phosphate uridylyltransferase

UTP—glucose-1-phosphate uridylyltransferase also known as glucose-1-phosphate uridylyltransferase (or UDP–glucose pyrophosphorylase) is an enzyme associated with glycogenesis. It synthesizes UDP-glucose from glucose-1-phosphate and UTP; i.e.,

glucose-1-phosphate + UTP $\rightleftharpoons$ UDP-glucose + pyrophosphate

Examples

Human genes encoding proteins with UTP—glucose-1-phosphate uridylyltransferase activity include:

UDP–glucose pyrophosphorylase 1
Identifiers
Symbol	UGP1
Entrez	7359
HUGO	12526
OMIM	191750
Other data
EC number	2.7.7.9
Locus	Chr. 1 q21-q22

UDP–glucose pyrophosphorylase 2
Identifiers
Symbol	UGP2
Entrez	7360
HUGO	12527
OMIM	191760
RefSeq	NM_006759
UniProt	Q16851
Other data
EC number	2.7.7.9
Locus	Chr. 2 p14-p13

External links

MeSH UDP+Glucose+Pyrophosphorylase

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor	Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD⁺ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor	Phosphoglycerate · Aspartate

2.7.3: N acceptor	Creatine

2.7.4: PO₄ acceptor	Phosphomevalonate · Adenylate · Nucleoside-diphosphate · Uridylate · Guanylate · Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)

Ribose-phosphate diphosphokinase · Thiamine diphosphokinase

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase	DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme RNA-directed DNA polymerase: Reverse transcriptase (Telomerase) DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

RNA nucleotidyltransferase	RNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase PNPase

Phosphorolytic
3' to 5' exoribonuclease

RNase PH · PNPase

Uridylyltransferase

Glucose-1-phosphate uridylyltransferase · Galactose-1-phosphate uridylyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

Recombinase (Integrase) · Transposase

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferase

Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases

2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases

2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases

2.7.13: protein-histidine	Protein-histidine pros-kinase · Protein-histidine tele-kinase · Histidine kinase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Metabolism: carbohydrate metabolism · glycogenesis and glycogenolysis enzymes

Glycogenesis

Phosphoglucomutase · UDP-glucose pyrophosphorylase · Glycogen synthase · Glycogen branching enzyme

Glycogenin

Glycogenolysis

extralysosomal: Glycogen phosphorylase · Debranching enzyme · Phosphoglucomutase

lysosomal: Alpha-glucosidase (Acid)

Regulation

Phosphorylase kinase · Phosphoprotein phosphatase

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)